Innovations in minimally invasive surgery and endoscopy platforms are contributing to a promising procedural field called Natural Orifice Translumenal Endoscopic Surgery (NOTES). Dr. Nathaniel Soper, professor and chair of surgery at Northwestern University Feinberg School of Medicine, and one of the first surgeons in the United States to perform NOTES procedures, joins host Dr. Mark Nolan Hill. Does early research on NOTES methods give us a perspective on long-term outcomes following the procedure? Do NOTES procedures beget any changes in role for nurses and other key contributors in the operating room?